Identifier: pathogenicmicroo00park (find matches)
Title: Pathogenic micro-organisms, including bacteria and Protozoa; a practical manual for students, physicians and health officers
Year: 1910 (1910s)
Authors: Park, William Hallock, 1863-1939 Williams, Anna Wessels, 1863- joint author
Subjects: Pathogenic bacteria Bacteria
Publisher: New York Philadelphia, Lea & Febiger
Contributing Library: Internet Archive
Digitizing Sponsor: Internet Archive

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e, the symptoms may be divided into two stages. Inthe first stage there is only an irregular fever with enlargement of the per-ipheral lymph nodes. In the second stage the fever becomes hectic, the TRYPANOSOMA. 565 pulse is constantly increased; there are neuralgic pains, partial oedemas anderythemas, trembling of the muscles, gradually increasing weakness, emacia-tion, and lethargy. The somnolence increases until a comatose condition isdeveloped and death occurs. In the second stage trypanosomes are alwaysfound in the cerebrospinal fluid. Throughout the disease they are usuallyfound in small numbers in the blood. Duration.—The first stage may last for several years; the second, fromfour to eight months. The percentage of deaths in cases reaching the secondstage is 100. Whether some in the first stage recover is not yet certain. T. gamhiense, the chief trypanosome pathogenic for human beings, is irreg-ularly pathogenic for some monkeys (Macacus rhesus and others), for dogs, Fig. 176
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Glossina palpalis, carrier of human trypano.somiasis. X-4 (KoUe iind Wassermann). cats, and rats. It is less pathogenic for mice, guinea-pigs, rabbits, and horses.Cattle and swine seem to lie refractory. Pathological Changes.—Congestion of the meninges; increased quantityof cerebros)iinal fluid; hypertrophy of spleen, liver, and lymphatic ganglia;diminished luPinoglol)in and number of red cells; number of leukocytes aboutnormal, but a relative increase of eosinophiles, mast cells, and lymphocytes.Enlargement of the superficial lymph nodes has been noted as an earlysymptom and has thus been made use of in diagnosis. Dutton and Toddfound that 91 per cent, of natives in the Congo Free State, who had ))osteriorcervical glands enlarged, showed trypanosomes in the punctured gland juice. Diagnosis of Trypanosomiasis in General.—This sliouUl l)e madeas early a.s possil)le in order to prevent the sj)rea(l of the disease. Anearly positive (lia<inosis can only l)e made by the determinatio

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