Faili:Protease mechanisms.png
Ukubwa wa hakikisho: piseli 800 × 307. Ukubwa zingine: piseli 320 × 123 | piseli 640 × 245 | piseli 1,437 × 551.
Faili halisi (piseli 1,437 × 551, saizi ya faili: 67 KB, aina ya MIME: image/png)
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Faili hili linatoka Wikimedia Commons. Maelezo yapo kule kwenye ukurasa wake wa maelezo unaonekana hapo chini.
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Muhtasari
| Maelezo |
English: Differences in cysteine and serine proteolysis mechanisms.
The protease (black) performs a nucleophilic attack on peptide substrate (red) to form a tetrahedral intermediate. This breaks down by ejection of the first product, the substrate C-terminus, to form the acyl-enzyme intermediate. Water replaces the first product and hydrolysis occurs via a second tetrahedral intermediate to regenerate free enzyme. Indicated differences are (a) the deprotonated cysteine, (b) aspartate (grey) not present in all cysteine proteases, (c) concerted deprotonation of serine, (d) aspartate hydrogen bonding, (e) amide protonation of the first leaving group, (f) alcohol protonation of the serine leaving group. |
| Tarehe | |
| Chanzo | Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge. |
| Mwandishi | Thomas Shafee |
Hatimiliki
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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| Tarehe/Saa | Picha ndogo | Vipimo | Mtumiaji | Maelezo | |
|---|---|---|---|---|---|
| sasa hivi | 20:56, 11 Oktoba 2013 | | 1,437 × 551 (67 KB) | Evolution and evolvability | User created page with UploadWizard |
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